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1992-1993
1. A. S. Ali, K. Yamamoto, A. M. El-Sayed,F. S. Habib, and Y.
Nakai : Molecular Interaction between Benzoic Acid and Florite and Complex
Formation. Chem. Pharm. Bull., 40: 467-471, 1992.
2. H. Egawa, S. Maeda, E. Yonemochi, T. Oguchi, K. Yamamoto,
and Y. Nakai : Solubility Parameter and Dissolution Behavior of Cefalexin
Powders with Different Crystallinity. Chem. Pharm. Bull. 40: 819-820,
1992.
3. T. Oguchi, J. Yamashita, E. Yonemochi, K. Yamamoto, and Y.
Nakai : Effects of Saccharide on the Decomposition of Cephalothin Sodium
and Benzylpenicilline Potassium in Freeze-Dried Preparations.
Chem. Pharm. Bull. 40: 1061-1063, 1992.
4. A. S. Ali, K. Yamamoto, A. M. El-Sayed, F. S. Habib, and Y.
Nakai : Molecular Behavior of Flufenamic Acid in Physical and Ground Mixtures
with Florite. Chem. Pharm. Bull., 40: 1289-1294, 1992.
5. T. Yamaguchi, M. Nishimura, R. Okamoto, T. Takeuchi, and K.
Yamamoto : Glass Formation of 4”-O-(4-Methoxyphenyl)acetyltylosin and
Physicochemical Stability of the Amorphous Solid. Int. J. Pharm.
85: 87-96, 1992.
6. K. Yamamoto : On the Drug Molecular States Dispersed in Cyclodextrin
Matrics. Yakugaku Zasshi 112: 161-173, 1992.
7. T. Uchida, E. Yonemochi, T. Oguchi, K. Terada, K. Yamamoto,
and Y. Nakai : Polymorphism of Tegafur : Physico-chemical Properties
of Four Polymorphs. Chem. Pharm. Bull. 41: 1632-1635, 1993.
8. T. Yamaguchi, M. Nishimura, R. Okamoto, T. Takeuchi, and K.
Yamamoto : Physico-chemical Stability of Glassy 16-Membered Macrolide Compounds.
Chem. Pharm. Bull. 41: 1812-1816, 1993.
9. E. Yonemochi, T. Oguchi, K. Yamamoto, and Y. Nakai : Acceleration
of the Addition Reaction of Succinic Anhydride and p-Nitroaniline in Synthetic
Aluminum Silicate. Advanced Powder Tochnol. 4: 41-48, 1993.
10. T. Hanawa, E. Yonemochi, T. Oguchi, and K. Yamamoto : Thermal Behavior
of Ground Mixtures of Heptakis(2,6-di-O-methyl)-??cyclodextrin and Benzoic
Acid. J. Inclusion Phenom. Mol. Recognit. Chem. 15: 91-101,
1993.
11. K. Yamamoto, K. Saito, H. Kawashima, E. Yonemochi, T. Oguchi,
and Y. Nakai : Molecular States of Pyrene in the Ground Mixtures with Cyclodextrins
Studied by Fluorescence Spectroscopy. Nippon Kagaku Kaishi
1993: 1141-1147, 1993.
12. T. Yamaguchi, M. Nishimura, H. Iguchi, R. Okamoto, T. Takeuchi,
K. Yamamoto : Improvement of Pharmaceutical Properties of 4’’-O-(4-methoxyphenyl)acetyltylosin
Using Solid Dispersion with Carboxymethylcellulo Yakuzaigaku
53: 221-228, 1993.
13. T. Yamaguchi, M. Nishimura, R. Okamoto, T. Takeuchi, K. Yamamoto
: Polymorphic Characterization of 3-O-Acetyl-4’’-O-isovalerytylosin
Yakuzaigaku. 53: 235-241, 1993.
14. T. Yamaguchi, M Nishimura, R. Okamoto, T. Takeuchi, K. Yamamoto
: Dissolution and Recrystallization Characteristics of Amorphous 3-O-Acetyl-4’’-O-isovaleryltylosin.
Yakuzaigaku 53: 249-256, 1993.
15. T. Oguchi : Effects of Saccharide Addition on the Crystallization
of Drugs during Freeze-Drying. Pharm. Tech. Jpn., 9:
263-270, 1993.
16. T. Uchida, E. Yonemochi, T. Oguchi, K. Terada, K. Yamamoto,
and Y. Nakai : Polymorphism of Tegafur: Physico-chemical Properties of
Four Polymorphs. Chem. Pharm. Bull. 41: 1632-1635, 1993.
1994-1995
17. K. Yamamoto, T. Oguchi, E. Yonemochi, T. Matsumura, and Y.
Nakai : Fluorometric Study of 2,5-Dipheny1oxazole in Ground Mixtures with
g-Cyclodextrin. Pharm. Res. 11: 331-336, 1994.
18. K. Matsumoto, Y. Nakai, E. Yonemochi, T. Oguchi, and K. Yamamoto
: Physicochemical Characterstics of Porous Crystalline Cellulose and Formation
of an Amorphous State of Ethenzamide by Mixing. Int. J. Pharm.
108: 167-172, 1994.
19. E. Yonemochi, K. Oda, S. Saeki, T. Oguchi, Y. Nakai, and
K. Yamamoto : Physicochemical Properties of Amorphous Ursdeoxycholic Acid
Obtained by Grinding. Chem. Pharm. Bull. 42: 1948-1950,
1994.
20. T. Hanawa, Y. Nakai, E. Yonemochi, T. Oguchi, and K. Yamamoto
: Effects of Vapor Pressure of Guest Compounds on the Bound Molar Ratio
to Heptakis-(2,6-di-O-methyl)-??cyclodextrin. Yakuzaigaku 54:
221-226, 1994.
21. H. Kawashima, E. Yonemochi, T. Oguchi, and K. Yamamoto :
Meta-Stable Complex Formation between 2,6-Di-O-methyl-??cyclodextrin and
Naphthalene During Sealed-Heating Process. Chem. Pharm. Bull.,
42: 727-729, 1994.
22. H. Kawashima, E. Yonemochi, T. Oguchi, and K. Yamamoto :
Complex Formation between Naphthalene and Di-methyl-??cyclodextrin by Heating
in a Sealed Ampoule. J. Chem. Soc. Faraday Trans. 90:
3117-3119, 1994.
23. A. Watanabe, T. Hanawa, M. Sugihara, and K. Yamamoto : Release
Profiles of Phenytoin from New Oral Dosage Form for the Elderly.Chem. Pharm.
Bull. 42, 1642-1645, 1994.
24. T. Ushio and K. Yamamoto : High-Performance Liquid Chromatography
of Enantiomers of {2-[4-(3-Ethoxy-2-hydroxypropoxy)phenylcarbamoyl]ethyl}-dimethylsulfoniumu-p-toluenesulfonate (Suplatast
tosilate) on a Cellulose Tris-3,5-dimethylphenyl-carbamate Column.
J. Chromatogr. A 684: 235-242, 1994.
25. T. Oguchi, K. Matsumoto, E. Yonemochi, Y. Nakai, and K. Yamamoto
: Dissolution Studies in Organic Solvents for Evaluating Hydrogen-Bond
Matrix of Cellulose in the Ground Mixture. Int. J. Pharm. 113:
97-102, 1995.
26. T. Hanawa, Y. Nakai, E. Yonemochi, T. Oguchi, and K. Yamamoto :
Characterization of Thermal Behavior of Physical Mixtures of Heptakis(2,6-di-○-methyl)-??cyclodextrin
with Benzoic Acid of p-Hydroxybenzoic Acid Esters. Netsu Sokutei
22: 11-15, 1995.
27. T. Oguchi, E. Yonemochi, and K. Yamamoto : Freeze-Drying of Drug-Additive
Binary Systems. Effects of Saccharide Addition on the Crystallization Sodium
in Frozen Aqueous Solution. Pharm. Acta Helv. 70: 113-116,
1995.
28. K. Moribe, E. Yonemochi, T. Oguchi, Y. Nakai, and K. Yamamoto :
Peculiar Peak Shifts in the IR Spectrum of Benzoic Acid Crystals by Compression
with Methylated Additives. Chem. Pharm. Bull. 43: 666-670,
1995.
29. E. Yonemochi, M. Kojima, A. Nakatsuji, S. Okonogi, T. Oguchi,
Y. Nakai, and K. Yamamoto : Thermal Behavior of Methyl p-Hydroxybenzoate
in Controlled-Pore Glass Solid Dispersion. J. Colloid lnterface Sci.
173: 186-191, 1995.
30. S. Maeda, Y. Nakai, E. Yonemochi, T. Oguchi, and K. Yamamoto
: Determination of Partial Solubility Parameters of Lactose and Its Application
to Solubility Evaluation. Yakugaku Zasshi 115: 234-240, 1995.
31. H. Kawashima, E. Yonemochi, T. Oguchi, and K. Yamamoto :
Factors Affecting the Formation in the Solid State of the Metastable Complex
between Naphthalene and Dimethyl-??Cyclodextrin. J. Inclusion Phenom.
Mol. Recognit. Chem. 23: 65-72, 1995.
32. T. Hanawa, R. Ikoma, A. Watanabe, M. Sugihara, T. Oguchi,
and K. Yamamoto : Dissolution Behavior of Acetaminophen from Powder and
Tablets of Ground Mixture of Acetaminophen with Florite RE and Polyethylene
Glycol 6000. Jpn. J. Hosp.Pharm. 21: l-8, 1995.
33. A. Watanabe, T. Hanawa, M. Sugihara, and K. Yamamoto : Development
and Pharmaceutical Properties of a New Oral Dosage Form of Theophylline
using Sodium Caseinate for the Possible Use in Elderly Patients.
Int. J. Pharm. 117: 23-30, 1995.
1996-1997
34. K. Matsumoto, Y. Nakai, E. Yonemochi, T. Oguchi, and K. Yamamoto
: Aspirin Hydrolysis in Mixtures with Porous Crystalline Cellulose.
Drug Stability 1: 92-97, 1996.
35. M. Fukahori, K. Kakinuma, M. Seki, H. Takahashi, Y. Uchino, H.
Sato, and K. Yamamoto : Effects of Added Lower Alcohols on Solubilized
Tocopherol Acetate Sorphon to Polyethylene Film in Aqueous Solution.
Chem.Pharm.Bull. 44: 196-200, 1996.
36. D. Watanabe, M. Ohta, Z. J. Yang, E. Yonemochi, T. Oguchi,
and K. Yamamoto : Formation of a Heptais-(2,6-di-O-methyl)-??cyclodextrin-p-Nitrophenol
Inclusion Compound by Sealed-Heating. Chem. Pharm. Bull. 44:
833-836, 1996.
37. K. Yamamoto, T. Nakao, E. Yonemochi,
and T. Oguchi : Time Resolved Fluorescent Analysis for
Sealed Heating of Dimethyl-??cyclodextrin and Naphthalene System.,
Journal of Inclusion Phenomena and Molecular Recognition in Chemistry
25: 121-124, 1996.
38. T. Oguchi, K. Kojima, D. Watanabe, E. Yonemochi, and K. Yamamoto
: Preparation of Inclusion Complexes of 1-Adamantanol with Heptakis-(2,6-di-O-methyl)-??cyclodextrin
by Sealed-Heating. Yakuzaigaku 56: 92-102, 1996.
39. K. Yano, N. Takamatsu, S. Yamazaki, K. Sako, S. Nagura, S.
Tomizaw, J. Shimaya, and K. Yamamoto : Crystal Forms, Improvements of Dissolustion
and Absorption of Poorly water-soluble (R)-1-[2,3-Dihydro-1-(2’-methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea
(YM022). Yakugaku Zasshi 116: 639-646, 1996.
40. T. Ushio, K. Endo, and K. Yamamoto Physicochemical Properties
of Suplatast Tosilate Racemate and Enantiomers, Yakugaku Zasshi 116:
866-875, 1996.
41. T. Ushio, R. Tamura, H. Takahashi, N. Azuma, and K. Yamamoto :
Unusual Enantiomeric Resolution Phenomenon Observed upon Recrystallization
of a Racemic Compound. Angew. Chem. Int. Ed. Engl. 35: 2372-2374,
1996.
42. K. Yano, A. Kajiyama, S. Yamazaki, Y. Matsumura, K. Watanabe,
and K. Yamamoto : ln vitro Stability and in vivo Absorption Studies of
Colloidal Particles Formed from a Solid Dispersion System. Chem .Pharm.Bull.
44: 2309-2313, 1996.
43. Z. Yang, E. Yonemochi, H. Seki, K. Yano, K. Yamamoto : Molecular
Interaction in Solvents between Pharmaceutical Excipients and Water Insoluble
Drug (r)-1-[2,3-Dihydro-1-(2’-methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methyl-phenyl)urea.
Yakuzaigaku 56: 224-231, 1996.
44. K. Matumoto, T. Kimura, Y. Nakai, E. Yonemochi, T. Oguchi,
Y. Yamamoto : Relationship between the Physical Properties of Various Lactoses
on the Market and Characteristics of Their Tablets. Yakuzaigaku
57: 1-7, 1997.
45. S. Ito, Y. Kobayashi, M. Nishimura, K. Matsumoto, S. Itai,
and K. Yamamoto : Effect of Pulverization on Dehydration Behavior of Crystals
of GK-128, a Serotonin 3 Receptor Antagonist. J. Pharm. Sci.
85: 1117-1122, 1997.
46. S. Okonogi, E. Yonemochi, T. Oguchi, S. Puttipipatkhachorn,
and K. Yamamoto : Enhanced Dissolution of Ursodeoxycholic Acid from the
Solid Dispersion. Drug Dev. Ind. Pharm. 23: 1-7, 1997.
47. S. Ito, M. Nishimura, Y. Kobayashi, S. Itai, and K. Yamamoto
: Characterization of Polymorphs and Hydrates of GK-128, a Serotonin 3
Receptor Antagonist. Int. J. Pharm. 151: 133-143, 1997.
48. E. Yonemochi, Y. Ueno, T. Ohmae, T. Oguchi, S. Nakajima,
and K. Yamamoto : Evaluation of Amorphous Ursodeoxychohc Acid by Thermal
Methods. Pharm. Res. 14: 798-803, 1997.
49. S. Piyarom, E. Yonemochi, T. Oguchi, and K. Yamamoto : Effects
of Grinding and Humidification on the Transformation of Conglomerate to
Racemic Compound in Optically Active Drugs. J. Pharm. Pharmacol.
49: 384-389, 1997.
50. S. Limmatvapirat, K. Yamaguchi, E. Yonemochi, T. Oguchi,
and K. Yamamoto : A 1 : 1 Deoxycholic Acid-Salicylic Acid Complex.
Acta Cryst. C53: 803-805, 1997.
51. K. Yano, A. Kajiyama, N. Itoh, J. Shimaya, and K. Yamamoto
: Improvement of Bioavailability of Poorly Water-soluble Drug by Nanoparticles
from a Solid Dispersion System. Yakuzaigaku 57: 95-101,
1997.
52. S. Lim matvapifat, E. Yonemochi, T. Oguchi, and K. Yamamoto
: Complex Formation between Deoxycholic Acid and Menadione by Grinding
and Sealed Heating Methods. Chem. Pharm. Bull. 45: 1358-1362,
1997.
53. F. Usui, K. Maeda, A. Kusai,K. Nishimura, and K. Yamamoto
: Inhibitory Effects of Water-Soluble Polymers on Pfecipitation of RS-8359.
Int. J. Pharm. 154: 59-66, 1997.
54. K. Yano, A. Kajiyama, M. Hamada, and K. Yamamoto : Constitution
of Colloidal Particles Formed from a Solid Dispersion System. Chem.
Pharm. Bull. 45: 1339-1344, 1997.
55. T. Oguchi, Y. Tozuka, S. Okonogi, E. Yonemochi, and K. Yamamoto
: Improved Dissolution of Naproxen from Sohd Dispersions with Porous Additives.
Yakuzaigaku 57: 168-173, 1997.
56. S. Okonogi, T. Oguchi, E. Yonemochi, S. Puttipipatkhachorn,
and K. Yamamoto : Improved Dissolution of Ofloxacin via Solid Dispersion.
Int. J. Pharm. 156: 175-180, 1997.
57. K. Matsumoto, Y. Nakai, E. Yonemochi, T. Oguchi, and K. Yamamoto, Aspirin Hydrolysis in Mixtures with Porous Crystalline Cellulose., Drug Stability 1: 92-97, 1997.
58. M. Fukahori, K. Kakinuma, M. Seki, H. Takahashi, Y. Uchino, H. Sato, and K. Yamamoto, Effects of Added Lower Alcohols on Solubilized Tocopherol Acetate Sorption to Polyethylene Film in Aqueous Solution. , Chem. Pharm. Bull. 44: 196-200, 1997.
1998-1999
59. K. Matsumoto, Y. Nakai, E. Yonemochi, T. Oguchi and K, Yamamoto
: Effect of Pore Size on the Gaseous Adsorption of Ethenzamide on Porous
Crystalline Cellulose and the Physicochemical Stability of Ethenzamide
after Storage. Chem. Pharm. Bull. 46: 314-318, 1998.
60. S. Limmatvapirat, E. Yonemochi, T. Oguchi and K. Yamamoto
: Mechanochemical Complexation between Deoxycholic Acid and Salicylic Acid.
J. Incl. Phenom. Recog. Chem., 31: 367-379, 1998.
61. H. Kawashima, E. Yonemochi, T. Oguchi, and K. Yamamoto :
The Effect of Water Content and Crystalliniyt of the Heptakis-(2,6-di-O-methyl)-?-cyclodextrin
on the Physicochemical Properties of a Sealed Heated Compound with Naphthalene.
J. Soc. Powder Tech. Jpn. 35: 353-359, 1998.
62. T. Oguchi, H. Yamasato, S. Limmatvapirat, E. Yonemochi and
K. Yamamoto : Structural Change and Complexation of Strictly Linear Amylose
Induced by Sealed-Heating with Salicylic Acid. J. Chem. Soc. Faraday
Trans. 94: 923-927, 1998.
63. Y. Ueno, E. Yonemochi, T. Tozuka, S. Yamamura, T. Oguchi
and K. Yamamoto : Charaterization of Ursodeoxycholic Acid Amorphous Prepared
by Spray-Drying Method. J. Pharm. Pharmcol. 50: 1213-1219, 1998.
64. Y. Tozuka, E. Yonemochi, T. Oguchi and K. Yamamoto : Fluorometric
Studies of Pyrene Adsorption on Porous Crystalline Cellulose. J.
Colloid Int. Sci. 205: 501-505, 1998.
65. T. Oguchi, S. Limmatvapirat, C. Takahashi, S. Sungthongjeen,
W. S. Choi, E. Yonemochi and K. Yamamoto : Effect of Guest Species on Inclusion
Compound Formation of Deoxycholic Acid by Co-grinding. Bull. Chem.
Soc. Jpn. 71: 1573-1579, 1998.
66. E. Yonemochi, S. Kitahara, S. Maeda, S. Yamamura, T. Oguchi and
K. Yamamoto : Physicochemical Properties of Amorphous Clarithromycin
obtained by Grinding and Spray Drying., Eur. J. Pharm. Sci. 6: 324-329, 1998.
67. E. Yonemochi, S. Kitahara, S. Maeda, S. Yamamura, T. Oguchi and K. Yamamoto, Physicochemical Properties of Amorphous Clarithromycin Obtained by Grinding and Spray Drying, Eur. J. Pharm. Sci. 6: 324-329, 1998.
68. F. Usui, K. Maeda, A. Kusai, M. Ikeda, K. Nishimura, and K. Yamamoto, Dissolution Improvement of 3RS-8359 by the Solid Dispersion Prepared by the Solvent Method. , Int. J. Pharm. 170: 247-256, 1998.
69. M. Ohta, Y. Tozuka, T. Oguchi and K. Yamamoto, Comparison of Crystallinity of Cefditoren Pivoxil Determined by X-Ray, Differential Scanning Calorimetry and Microcalorimetry, Chem.Pharm.Bull. 47: 1638-1640, 1999.
70. E. Yonemochi and K. Yamamoto, Interaction between Solid Drug and Pharmaceutical Additives, Netsu Sokutei 25: 111-116, 1999.
71. E. Yonemochi, S. Kitahara, S. Maeda, S. Yamamura, T. Oguchi and K. Yamamoto, Physicochemical Properties of Amorphous Clarithromycin obtained by Grinding and Spray Drying, Eur. J. Pharm. Sci. 7: 331-338, 1999.
72. S. Okonogi, T. Oguchi, E. Yonemochi, S. Puttipipatkhachorn and
K. Yamamoto, Physicochemical Properties of Ursodeoxycholic Acid in Solid
Dispersion with Controlled Pore Glass, J. Colloid Int. Sci. 216:
276-284, 1999.
2000-2001
73. S. Chutimaworapan, G. C Ritthidej, T. Oguchi, and K. Yamamoto, Controlled Release of Nifedipine from Microspheres Spray Dried with Eudragit and Polyvinylpyrrolidone, J. Pharm. Sci. Technol. Jpn. 60(3): 196-206, 2000.
74. T. Oguchi, K. Kazama, E. Yonemochi, S. Chutimaworapan, W. S. Choi, S. Limmatvapirat, and K. Yamamoto, Specific complexation of ursodeoxycholic acid with guest compounds induced by co-grinding, Phys. Chem. Chem. Phys. 2: 2815-2820, 2000.
75. S. Chutimaworapan, G. C. Ritthidej, T. Oguchi, and K. Yamamoto, Controlled Release of nifedipine from Microspheres Spray Dried with Eudragit and Polyvinylpyrrolidone, J. Pharm. Sci. Technol., Jpn. 60(1): 77-87, 2000.
76. Y. Tozuka, E. Yonemochi, T. Oguchi and K. Yamamoto, Molecular States of 2-Naphthoic Acid in Solid Disersions with Porous Crystalline Cellulose, as Investigated by Fluorescence Spectroscopy, Bull. Chem. Soc., Jpn. 73: 1567-1572, 2000.
77. M. Ohta, Y. Tozuka, T. Oguchi, and K. Yamamoto, Water Vapor Adsorption Properties of Amorphous Cefditren Pivoxil Evaluated by Adsorption Isotherms and Microcalorimetry, Drug Dev. Ind. Pharm. 26: 643-649, 2000.
78. T. Oguchi, K. Ishidoh, T. Hanawa, S. Piyarom, and K. Yamamoto, Inclution Compound Formation of ?-Cyclodextrin with Polyethylene Glycol Induced by Heat Treatment, J. Pharm. Sci. Technol., Jpn. 60(2): 139-147, 2000.
79. M. Ohta, Y. Tozuka, T. Oguchi and K. Yamamoto, Evaluation of Physicochemical Stability of Amorphous Cefditren Pixoxil, Using Modulated-Temperature Differential Scanning Calorimetry, J. Pharm. Sci. Technol., Jpn. 60(2): 160-165, 2000.
80. Y. Kobayashi, S. Ito, S. Itai, and K. Yamamoto, Physicochemical Properties and bioavailability of carbamazepine polymorphs and dihydrate, Int. J. Pharm. 193: 137-146, 2000.
81. S. Chutimaworapan, G. C. Ritthidej, T. Oguchi, and K. Yamamoto, Fast Release and Physicochemical Characteristics of Nifedipine Solid Dispersions with Poloxamers, J. Pharm. Sci. Technol., Jpn. 60 (1): 77-87, 2000.
82. A. Koda, S. Ito, S. Itai, and K. Yamamoto, Characterization of Chloramphenicol Palmitate From C and Absorption Assessments of Chloramphenicol Palmitate Polymorphs, J. Pharm. Sci. Technol., Jpn. 60 (1): 43-52, 2000.
83. L. M. Zhou, J. Sirithunyalug, E. Yonemochi, T. Oguchi and K. Yamamoto, Complex Formation between Erythritol and 4-Hexylresorcinol, J. Thermal Anal. Calorimetry 59: 951-960, 2000.
84. M. Ono, Y. Tozuka, T. Oguchi and K. Yamamoto, Effect of dehydration temperatures on moisture absorption and dissolution behavior of theopphylline, Chem.Pharm. Bull. 49: 1526-1530, 2001.
85. J. Nunthanid, S. Puttipipatkhachorn, K. Yamamoto, and G. E. Peck, Physical Properties and Molecular Behavior of Chitosan Films, Drug Dev. Ind. Pharm. 27: 143-157, 2001.
86. H.Ishii, K. Yamamoto, T. Oguchi, and Y. Tozuka, Effect of Temperature
on Amorphous Form of Sparingly(Poorly) Water-Soluble Drug Prepared by Grinding,
J. Jpn. Pharm. Mach. & Eng. 10(2): 6-12, 2001.
87. S. Chutimaworapan, G. C Ritthidej, T. Oguchi, and K. Yamamoto, Controlled Release of Nifedipine from Coevaporates Prepared with Eudragit and Poloxamer, J. Pharm. Sci. Technol. Jpn. 61(1): 21-33, 2001.
88. T. Uchino, Y. Tozuka, T. Oguchi, and K. Yamamoto, The Change of the Structure of Amylose During the Inclusion of 2-Naphthol in Sealed-heating Process, J. Inclusion. Phenom. Macro. Chem. 39: 145-149, 2001.
89. K. Nakamura, K. Katagai, K. Mori, N. Higo, S. Sato, K. Yamamoto, Transdermal administration of salmon calcitonin by pulse depolarization-iontophoresis in rats, Int. J. Pharm. 218: 93-102, 2001.
90. T. Suzuki, H. Kikuchi, E. Yonemochi, K. Terada, and K. Yamamoto, Interaction of Microcrystalline Cellulose and Water in Granules Prepared by a High-Shear Mixer, Chem. Pharm. Bull. 49(4): 373-378, 2001.
91. T. Suzuki, H. Kikuchi, S. Yamamura, K. Terada, and K. Yamamoto, The change in characteristics of microcrystalline cellulose during wet granulation using a high-shear mixer, J. Pharm. Pharmcol. 53: 609-616, 2001.
2002-2003
92. Y. Tozuka, E. Tashiro, E. Yonemochi, T. Oguchi, and K. Yamamoto, Solid-state fluorescence study of naphthalene adsorption on porous material, J.Colloid Interface Sci., 248, 239-243 (2002)
93. K. Itoh, Y. Tozuka, T. Oguchi, and K. Yamamoto, Improvement of Physicochemical Properties of N-4472 Part I Formulation Design by Using Self-Microemulsifying System, Int. J. Pharm., 238, 153-160 (2002)
94. T. Uchino, Y. Tozuka, W. S. Choi, T. Oguchi, and K. Yamamoto, Inclusion Behavior of Benzoic Acid Analogues to Linear Amylose by the Sealed-Heating Method, J. Pharm. Sci. Technol., Jpn., 62, 58-66 (2002)
95. M. Ono, Y. Tozuka, T. Oguchi, S. Yamamura, and K. Yamamoto, Effects of Dehydration Temperature on Water Vapor Adsorption and Dissolution Behavior of Carbamazepine, Int. J. Pharm., 239, 1-12 (2002)
96. T. Oguchi, Y. Tozuka, T. Hanawa, M. Mizutani, N. Sasaki, S. Limmatvapirat, and K. Yamamoto, Elucidation of Solid-State Complexation in Ground Mixtures of Cholic Acid and Guest Compounds, Chem. Pharm. Bull., 50, 887-891 (2002)
97. Y. Tozuka, A. Ito, H. Seki, T. Oguchi, and K. Yamamoto, Characterization and Quantitation of Clarithromycin Polymorphs by Powder X-ray Diffractometry and Solid-State NMR Spectroscopy. Chem. Pharm. Bull., 50, 1128-1130 (2002)
98. H. Ishii, K.Yamaguchi, H. Seki, S. Sakamoto, Y. Tozuka, T. Oguchi, and K. Yamamoto, Crystal Structure of the Alcholates and the Ansolvate of PNU-97018, an Angiotensin II Recepter Antagonist, Chem.Pharm. Bull., 50, 1022-1027 (2002)
99. K. Itoh, S. Matsui, Y. Tozuka, T. Oguchi and K. Yamamoto, Improvement of Physicochemical Properties of N-4472 Part II. Characterization of N-4472 Microemulsion and the Enhanced Oral Absorption, Int. J. Pharm., 246, 75-83 (2002)
100. T. Uchino, Y. Tozuka, T. Oguchi, and K. Yamamoto, Inclusion Compound Formation of Amylose by Sealed-Heating with Salicylic Acid Analogues, J. Incl. Phenom.,43, 31-36 (2002)
101. A. Wongmekiat, Y. Tozuka, T. Oguchi, and K. Yamamoto, Formation of Drug Fine Particle by Cogrinding with Cyclodextrins. Part I: The Use of b-Cyclodextrin Anhydrate and Hydrate, Pharm. Res.19, 1869-1874 (2002)
102. K. Itoh, Y. Tozuka, T. Oguchi, and K. Yamamoto, Improvement of Physicochemical Properties of N-4472. Part III. VC/N-4472 Complex Formation and Self-association in Aqueous Solution, Chem.Pharm. Bull., 51, 40-45 (2003)
103. Y. Tozuka, T. Oguchi, and K. Yamamoto, Adsorption and Entrapment of Salicylamide Molecules into the Mesoporous Structure of Folded Sheets Mesoporous Material (FSM-16), Pharm. Res., 20, 926-931 (2003)
104. T. Oguchi, N. Sasaki, T. Hara, Y. Tozuka, and K. Yamamoto, Differentiated Thermal Crystallization from Amorphous Chenodeoxycholic Acid between the Ground Speciments Derived from the Polymorphs Int. J. Pharm.,253,81-88 (2003)
105. T. Fukami, K. Yamaguchi, Y. Tozuka, K. Moribe, T. Oguchi, and K. Yamamoto, Novel Channel Structures of Bile Acid-Guest Inclusion Complex Formed between Ursodesoxycholic Acid and Phenanthlene, Chem. Pharm. Bull., 51, 227-229 (2003)
106. K. Itoh, A. Pongpeerapat, Y. Tozuka, T. Oguchi, and K. Yamamoto, Nanoparticle Formation of Poorly Water-soluble Drugs from Ternary Ground Mixtures with PVP and SDS, Chem.Pharm. Bull., 52, 171-174 (2003)
107. H. Y. Chung, E. Yonemochi, T. Saitoh, K. Terada, Y. Tozuka, T. Oguchi, K. Yamamoto, H. Y-. Chung, and W. S. Choi, Factors affecting the apparent solubility of ursodeoxycholic acid in the grinding process, Int. J. Pharm., 255, 49-56 (2003)
108. S. Yada, M. Ohya, Y. Ohuchi, T. Hamaura, N. Wakiyama, F. Usui, A. Kusai, and K. Yamamoto, Solid phase transition of CS-891 enantiotropes during grinding, Int. J. Pharm., 255, 69-79 (2003)
109. T. Oguchi, K. Kazama, T. Fukami, E. Yonemochi, and K. Yamamoto, Specific Complexation of Ursodeoxycholic Acid with Guest Compounds Induced by Co-grinding. II. Effect of Grinding Temperature on the Mechanochemical Complexation, Bull. Chem. Soc. Jpn., 76, 515-521 (2003)
110. Y. Tozuka, D. Kawada, T. Oguchi, K. Yamamoto, Supercritical carbon dioxide treatment as a method for polymorph preparation of deoxycholic acid. Int. J. Pharm., 263, 45-50(2003)
111. A. Wongmekiat, Y. Tozuka, T. Oguchi, K. Yamamoto: Formation of fine drug particle by cogrinding with cyclodextrins: Part II: The Influence of moisture condition during cogrinding process on fine particle formation, Int. J. Pharm., 265, 85-93 (2003)
112. K. Moribe, P. Sujimon, Y. Tozuka, E. Yonemochi, T. Oguchi, K. Yamamoto: Structural change and moisture sorption behavior of dl-valine induced by grinding, STP Pharma Sci., 13, 381-386 (2003)
2004-2005
113. Y. Tozuka, S. Sasaoka, A. Nagae, K. Moribe, T. Oguchi, and K. Yamamoto,
Rapid adsorption and entrapment of benzoic acid molecules into the
mesoporous silica (FSM-16), J. Colloid Interface Sci., in press.
114. K. Moribe, A. Pongpeerapat,Y. Tozuka, and K. Yammaoto., Drug nanoparticle
formation from Drug/HPMC/SDS ternary ground mixtures, Pharmazie, in press
115. Y. Tozuka, T. Fujito, K. Moribe, and K. Yammaoto, Ibuprofen-cyclodextrin
inclusion complex formation using supercritical carbon dioxide, J. Incl.
Phenom. Macrocyc. Chem.,in press.
| Reviews |
1. K. Yamamotoand E. Yonemochi : Anomalous Properties of Drug
Molecules in Micro Porous Matrices. Pharm. Tech. Jpn. 8: 431-439,
1992.
2. K. Yamamoto : Properties of Crystalline Pharmaceuticals and
the Characterizaiton. Yakuji Shinpou 1271: 1188-1192, 1992.
3. T. Oguchi : Effects of Saccharide Addtion on the Crystallization
of Drug During Freeze-Drying. Pharm. Tech, Jpn. 9: 263-270,
1993.
4. K. Yamamoto : Moisture in Pharmaceutics. Inochi to Kusuri
10: 5, 1994.
5. K. Yamamoto : Considering Crystal and Amorphous. J.
P. E. C. Information 3: 23, 1994.
6. K. Yamamoto : Improvement of Dissolution Behavior of Insoluble
Drugs. Pharm. Tech. Jpn. 11: 985-993, 1995.
7. K. Yamamoto : Organic-Inorganic Composite Material.
Powder and Industry 27: 56-58, 1995.
8. K. Yamamoto: Control of Physicochemical Properties of Organic
molecules by Complexation. Powder and Industry 27: 29-35,
1995.
9. T. Oguchi and K Yamamoto : Recent Technology of Grinding and
Pharmaceutical Technology. J. Jpn. Soc. Pharm. Machinery Eng.
4: 32-38, 1995.
10. E. Yonemochi and K. Yamamoto : Series of Powder Technology and
Analysis, Chapter 1. Averaged Information from Whole Sample Analysis 1.3.
1. Infrared Analysis (Organic). J. Soc. Powder Tech Jpn. 32:
337-346, 1995.
11. K. Yamamoto : Mechanochemical Effects on the Molecular States
of Solid Drug. Pharm. Tech. Jpn. 12: 859-863, 1996.
12. E. Yonemochi and K. Yamamoto : Automatic Gravimetric Water
Vapor Adsorption Analyzer and Its Applicatrion for Characterization of
Solid Dosage Form, Pharm. Tech. Jpn. 12: 1235-1241, 1996.
13. K. Yamamoto : Analysis of Physicochemical Interaction between
Drug Molecules and Pharmaceutical Excipients. Pharm. Tech. Jpn.
13: 403-415, 1997.
14. K. Yamamoto : Polishing-up of Information and Workshop.
J. Jpn. Soc. Pharm. Machinery Eng. 6: 2-3, 1997.
15. K. Yamamoto : Wonder of Molecular Ordering. Pharmacia
34: 325-327, 1998.
| 総説(日本語) |
1. 山本恵司:製剤中における水分。生命とくすり,10, 5 (1994)
2. 山本恵司:結晶と非晶を考える。J.P.E.C.Information, 3, 2-3 (1994)
3. 山本恵司:難溶性薬物の溶解性改善。 PHARM TECH JAPAN, 11, 985-993 (1995)
4. 山本恵司:有機無機複合材料。粉体と工業,27(2), 56-58 (1995)
5. 山本恵司:有機物の複合化による機能制御。粉体と工業,27(4), 29-35 (1995)
6. 小口敏夫, 山本恵司:最近の粉砕技術と製剤工学。製剤機械技術研究会誌, 4, 32-38 (1995)
7. 米持悦生, 山本恵司:粉体工学・分析講座 第一章 試料全体の分析による平均的情報 1.3振動スペクトル分析1.3.1赤外分析(有機質)。粉体工学会誌,32,
337-346 (1995)
8. 山本恵司:固体医薬品の分子状態におよぼすメカノケミカル効果. PHARM TECH JAPAN.,12,859-863(1996)
9. 米持悦生, 山本恵司:重量法による水蒸気目動吸着測定装置とその製剤物性測定への応用. PHARM TECH JAPAN, 12, 1235-1241(1996)
10. 山本恵司:製剤添加剤と医薬品の相互作用の解析. PHARM TECH JAPAN., 13, 403-415(1997)
11. 山本恵司:情報のポリッシュとワークショップ. 製剤機械技術研究会誌, 6, 2-3(1997)
12. 山本恵司:分子の並び方の不思議. ファルマシア, 46, 128-130(1998)
13. 山本恵司:医薬品製剤の化学. 化学と教育, 34, 325-327(1998)
14. 米持悦生, 山本恵司:固形医薬品と製剤添加剤との相互作用. 熱測定, 25, 111-116(1998)
15. 山本恵司:難溶性薬物の製剤設計〜基礎と応用〜, 薬事新報, 27, 1147-1150(1999)
16. 山本恵司:薬剤師国家試験について考える. 日本薬剤学会会報, 15, 3(1999)
17. K.Yamamoto:Methods Used for Improving Dissolution and Adsorption Characteristics of Poorly-Soluble Drugs.
Srinakharinwirot J.Pharm.Sci. 5, 84-100(2000)
18. 山本恵司:Quality of Lifeと医薬品の品質およびPDA国際京都会議に臨んで. PHARM TECH JAPAN, 16, 31-52(2000)
19. 山本恵司:グローバル対応の最新情報発信基地として. 薬事日報9336, 4(2000)
20. 山本恵司:21世紀における国際化. 薬事新報, 37, 22(2001)
21. 山本恵司, 小口敏夫:医薬品のアモルファスの研究. 千葉大学大学院薬学研究院の成果−薬学の世界をのぞく, 千葉日報(2001)
22. 山本恵司, 小口敏夫:シクロデキストリンを製剤に. 千葉大学大学院薬学研究院の成果−薬学の世界をのぞく, 千葉日報(2001)
23. 山本恵司:ヘルスサイエンスとの融合を高め新たな薬学領域の可能性を探る. 調剤と情報, 8, 12 (2002)
| Books |
l. K. Yamamoto : Topics in Pharmaceutical Sciences 1993, Medpharm
Scientific Publishers, Stuttgart, 1994.
2. K. Yamamoto and S. Okonogi : Chapter 29, Adsorption
of Pharmaceutical Organic Compounds onto Porous Materials. Surface
of Nanoparticles pp. 763-780, Marcel Dekkar, 1998.
3. K. Yamamoto : Improvement of Solubility and Absorption.,
Sciences of Evaluating and Improving Bioavailability of Pharmaceuticals.
pp. 115-131, Gendai Iryousha, 1998.
4. K. Yamamoto : Inclusion Compound Containing Pharmaceuticals
as a Guest., Handbook of Calorimetry and Thermal Analysis, p. 263,
Maruzen, 1998.
5. T. Oguchi : Characterization of Powdered Pharmaceuticals by
Means of Calorimeter., Handbook of Calorimetry and Thermal Analysis, p.
266, Maruzen, 1998.
| 単行書(日本語) |
1. K. Yamamoto: Topics in Pharmaceutical Sciences 1993, Medpharm Scientific
Publishers, Stuttgart (1994)
2. 山本恵司(分担執筆):薬物バイオアベイラビリティ評価と改善の科学, 東京, 現代医療社(1998)
3. 山本恵司(分担執筆):熱量測定・熟分折ハンドブック, 東京, 丸善(1998)
4. 米持悦生(分担執筆):熱量測定・熱分折ハンドブック, 東京, 丸善(1998)
5. 小口敏夫(分担執筆):熱量測定・熱分析ハンドブック, 東京, 丸善(1998)
6. K.Yamamoto:Adsorption of Pharmaceutical Organic Compounds onto Porous Materils.
in Surfaces of Nanoparticles and Porous Materials, J.A.Schwarz, and C.I.Contescu, eds., Marcel Dekker,
New York, U.S.A., pp.763-780(1999)
7. 山本恵司(編集及び分担翻訳):マーチン物理薬剤学, 東京, 廣川書店(1999)
8. 小口敏夫(分担翻訳):マーチン物理薬剤学, 東京, 廣川書店(1999)
9. 山本恵司(分担執筆):粒子設計工学・新素材開発のキーテクノロジー, 東京, 産業図書(1999)
10. 山本恵司(分担執筆):物盤物理化学・製剤学へのアプローチ, 東京, 南江堂(1999)
11. 山本恵司(編集および分担執筆), 小口敏夫(分担執筆):総合製剤学, 東京, 南山堂(2000)
12. 山本恵司(分担執筆):比表面積測定法, 日本薬局方技術情報2001, 東京, 株式会社じほう, 204-205(2001)
13. 山本恵司(分担執筆):包接化合物による機能設計, 微粒子工学大系, 東京, フジ・テクノシステム, 568-571(2001)
14. K. Moribe, K. Maruyama: Development of the long-circulating liposomal formulation of polyene macrolide antibiotics for infectious disease. In : Recent Res. Devel. Chem. Pharm. Sciences, India, Transworld Research Network, pp.137-154 (2002)
15. 山本恵司 (編集及び分担執筆):固体医薬品の物性評価, 東京, 株式会社 じほう (2003)
| 学会発表 |
1994-1995
1. 井紀孝, 米持悦生, 小口敏夫, 山本恵司:シクロデキストリンとの混合粉砕過程におけるp-ジメチルアミノベンゾニトリル分子挙動の固体蛍光測定による検討。日本薬学会第114年会講演要旨集4 16 (1994)
2. 小島一也, 米持悦生, 小口敏夫, 山本恵司:1-アダマンタノールとジメチル-β-シクロデキストリンの密封加熱過程における分子状態変化。日本薬学会第114年会講演要旨集4 16 (1994)
3. 川島弘行, 米持悦生, 小口敏夫, 山本恵司:ジメチル-β-シクロデキストリンとの密封加熱過程におけるナフタレンの分子挙動。日本薬学会第114年会講演集4 17 (1994)
4. 高橋千香子, 米持悦生, 小口敏夫, 山本恵司:混合粉砕及び密封加熱によるデオキシコール酸とフェナントレンの包接化合物の形成。日本薬剤学会第10年会講演要旨集136 (1994)
5. 山本恵司:難溶性薬物投与と非晶質化。第27回日本薬剤師会学術大会講演要旨集, 21-40 (1994)
6. 山本恵司:有機物の複合化による機能制御。POWDERTEC JAPAN 94講演要旨集, 4-1-1 (1994)
7. E. Yonemochi, H. Kawashima, T. Oguchi,
K. Yamamoto: Meta-Stable Complex Formation between Naphthalene and Dimethyl-b-Cyclodextrin
during Sealed Heating Process. Proceeding of the 7th International Cyclodextrins
Symposium, Tokyo Japan, 210-213 (1994)
8. E. Yonemochi, H. Kawashima, T. Oguchi,
K. Yamamoto: Complex Formation between Naphthalene and Dimethyl-b-Cyclodextrin
by Sealed Heating. Proceeding of 13th Pharmaceutical Technology Conference,
Strasbourg France, 128-134 (1994)
9. K. Yamamoto: Preparation and Characterization
Amorphous Drug. Proceeding of Recent Advances on Pharmaceutics and Pharmaceutical
Technology, Bangkok Thailand, OP-36 (1994)
10. T. Ushio*, R. Tamura*,
K. Yamamoto: Unusual Optical Enrichment of Supersaturated Solution Observed
upon Recrystallization. Proceeding of 5th International Symposium on Chiral
Discrimination, Stockholm Sweden, 25 (1994)
11. E. Yonemochi, T. Oguchi, K. Yamamoto:
Amorphization of Crystalline Drugs and Its Physicochemical Properties.
Proceeding of The Advances in Pharmaceutical Sciences, Singapore, 61-65 (1994)
12. T. Oguchi, M. Hindle*, H.
Chrystyn*, P. York*: Dry Powder Formulations of Gentamicin
for Inhalation. Pharm. Res., 12 (9), s-180 (1995)
13. 大前貴生, 米持悦生, 小口敏夫, 山本恵司:ウルソデオキシコール酸非晶質の溶解熱測定による比較。日本薬学会第115年会講演集4 12 (1995)
14. 星野良市, 米持悦生, 小口敏夫, 山本恵司:ノルフロキサシンの水和物形成過程に及ぼす粉砕の影響。日本薬学会第115年会講演集4 14 (1995)
15. S. Piyarom, E. Yonemochi, T. Oguchi,
K. Yamamoto : Conglomerate - Racemic Compound Transformation of Leucine
Induced by Grinding and Humidification. 日本薬学会第115年会講演集4 14 (1995)
16. 生塩孝則*, 田村類*,
山本恵司:再結晶により認められる抗アレルギー薬(トシル酸スプラタスト)の光学富化現象。日本薬学会第115年会講演集4 15 (1995)
17. 鳥海有美子*, 西村真理*,
松本慶太*, 伊藤修正*, 板井茂*, 根本正美*,
山本恵司:粉砕工程がGK-128(0.5水和物)の脱水挙動に及ぼす影響。日本薬学会第115年会講演集4 46 (1995)
18. 小島一也, 米持悦生, 小口敏夫, 山本恵司:密封加熱法によるジメチル-β-シクロデキストリンと1-アダマンタノールの新しい複合体の形成。日本薬学会第115年会講演集4 121 (1995)
19. 長谷川裕高, 米持悦生, 小口敏夫, 山本恵司:セリン-p-トルエンスルホン酸塩ラセミ体結晶の物理化学的変化。日本薬学会第115年会講演集4 122 (1995)
20. 戸塚裕一, 米持悦生, 小口敏夫, 山本恵司:蛍光プローブを用いた多孔性結晶セルロースへの薬品の吸着に関する研究。日本薬剤学会第11年会講演要旨集142 (1995)
21. 西村真理*, 鳥海有美子*,
板井茂*, 伊藤修正*, 山本恵司:水和物の相互転移と物理化学的性質に関する検討。日本薬剤学会第11年会講演要旨集144 (1995)
22. 中尾琢磨, 米持悦生, 小口敏夫, 山本恵司:時間分解蛍光法を利用したナフタレン-ジメチル-β-シクロデキストリン密封加熱物形成過程の解析。第39回日本薬学会関東支部大会講演要旨集45 (1995)
1996-1997
23. 山本恵司:固体医薬品の分子状態に及ぼすメカノケミカル効果。日本薬学会第116年会講演集1 68 (1996)
24. 前田秀栄*, 高橋春彦*,
木村孝良*, 山本恵司:非晶質寒天の徐放性経口投与製剤への応用。日本薬学会第116年会講演集4 14 (1996)
25. P. Sujimon, 米持悦生, 小口敏夫, 山本恵司:ラセミ混合物からラセミ化合物への転移過程に及ぼす粉砕の影響。日本薬学会第116年会講演集4 16 (1996)
26. 楊志軍, 米持悦生, 小口敏夫, 山本恵司,
関宏子, 矢野克彦*:HPMC, PVP及びHCO-60と難溶性医薬品との分子間相互作用。日本薬学会第116年会講演集4 17 (1996)
27. 松本奈々, 米持悦生, 小口敏夫, 山本恵司:シクロデキストリン類との混合系におけるp-ジメチルアミノベンゾニトリルの分子状態。日本薬学会第116年会講演集4 17 (1996)
28. L. Sontaya, 米持悦生, 小口敏夫, 山本恵司:混合粉砕法と密封加熱法によるデオキシコール酸とメナジオンの複合体形成。日本薬学会第116年会講演集4 17 (1996)
29. 梶山篤司*, 矢野克彦*,
山崎繁*, 伊藤直樹*, 高橋達也*, 松村吉祐*,
山本恵司:難溶性薬物の固体分散体化による消化管吸収性改善。日本薬学会第116年会講演集4 19 (1996)
30. 上野靖彦, 米持悦生, 小口敏夫, 山本恵司:噴霧乾燥法により調製したウルソデオキシコール酸非晶質のキャラクタリゼーション。日本薬学会第116年会講演集4 20 (1996)
31. 生塩孝則*, 田村類*,
山本恵司:新規アレルギー剤トシル酸スプラタストの多形現象。日本薬学会第116年会講演集4 60 (1996)
32. 中井洋一郎*, 松本和弘*,
前田秀栄*, 木村孝良*, 仲井由宣*, 山本恵司:崩壊剤含有ワックスマトリックス錠剤からのエテンザミドの溶出挙動とpH依存性。日本薬学会第116年会講演集4 66 (1996)
33. 米持悦生:乳糖の物性と製剤特性。第1回医薬品添加剤学術シンポジウム講演要旨集, 21-29 (1996)
34. 楊 志軍, 関宏子, 米持悦生, 矢野克彦, 山本恵司:製剤添加剤とNitrazepamとの溶液中での分子間相互作用。
第40回日本薬学会関東支部大会講演要旨集 78(1996)
35. 松本奈々, 米持悦生, 小口敏夫, 山本恵司:シクロデキストリン混合粉砕系でのp-ジメチルアミノベンゾニトリ
ルの分子状態−固体蛍光測定からの検討−。 第14回シクロデキストリンシンポジウム講演要旨集 34(1996)
36. Yuichi Tozuka, Etsuo Yonemochi, Toshio Oguchi, and Keiji Yamamoto:Study of Drug Adsorption on
Porous Additives by Using Fluorescence Spectroscopy. 11th Annual Meeting of American Association of
Pharmaceutical Scientists, Seattle,Invited and Contributed Papers Abstracts, s-256(1996)
37. T.Oguchi, M.Hindle, R.T.Forbes and P.York:Cromolyn Sodium:Characterization of a New
Polymorph. 11th Annual Meeting of American Association of Pharmaceutical Scientists, Seattle, Invited
and Contributed Papers Abstracts, s-173(1996)
38. 米持悦生, 上野靖彦, 小口敏夫, 山本恵司:非晶質ウルソデオキシコール酸の物理化学的性質。
第13回製剤と粒子設計シンポジウム講演要旨集 85(1996)
39. 山本恵司:製剤添加剤と医薬品の相互作用の解析。 第13回製剤と粒子設計シンポジウム講演要旨集 201(1996)
40. 山本恵司:医薬品の異物混入対策。 製剤機械技術研究会第6回大会講演要旨集 87(1996)
41. 山本恵司:熱分析の医薬品への応用。第31回熱測定講習会テキストU, 33(1996)
42. K. Yamamoto, T. Nakao, E. Yonemochi,
T. Oguchi: Time Resolved Fluorescence Analysis for Sealed Heating of Dimethyl-b-cyclodextrin
and Naphthalene System. Proceeding of the 8th International Cyclodextrin
Symposium, Budapest Hungary, 2-p10 (1996)
43. 山里浩明, 米持悦生, 小口敏夫, 山本恵司:サリチル酸との密封加熱によるアミロースの構造変化と包接化合物
形成。 日本薬剤学会第13年会講演要旨集174(1997)
44. S.Limmatvapirat, 米持悦生, 小口敏夫, 山本恵司:混合粉砕法によるデオキシコール酸とサリチル酸の包接化合物形成。
日本薬剤学会第13年会講演要旨集 176(1997)
45. 碓井富佐雄, 前田賀津子, 草井章富, 西村憲治, 山本恵司:水難溶性薬物RS-8359の水溶性高分子
マトリックス中への分散による溶出性改善。 日本薬剤学会第13年会講演要旨集 180(1997)
46. 北原進一, 米持悦生, 小口敏夫, 山本恵司:クラリスロマイシン非晶質状態のキャラクタリゼーション。 日本薬
剤学会第13年会講演要旨集 184(1997)
47. 小口敏夫, 米持悦生, 山本恵司, M.HindleandP。York:クロモグリク酸ナトリウムの多形とその吸湿挙動。
日本薬学会第117年会講演要旨集 4, 49(1997)
48. 戸塚裕一, 米持悦生, 小口敏夫, 山本恵司:製剤添加剤との混合によるLevofloxacinの蛍光特性変化。 日本薬学
会第117年会講演要旨集 4, 6(1997)
49. K.Yamamoto:Adsorption Phenomena in Pharmaceutical Solid, Proceedings of Pacific Basin Workshop
on Adsorption Science and Technology, Chiba, 64(1997)
50. T.Oguchi, Y.Tozuka, S.Okonogi, E.Yonemochi and K.Yamamoto:Improved Dissolutn on of Naproxen
from Solid Dispersionswith Porous Additives,Proceedings of the 1st Indochina Conference on
Pharmaceutical Sciences, Bangkok, 20(1997)
51. T,Oguchi, K.Kojima, D.Watanabe, E.Yonemochi and K.Yamamoto:Complexation between 1-Adamantanol and
Dimethyl-β-cyclodextrin by Sealed Heating Process, Proceedings of Pharmaceutical Apphcations of
Cyclodextrins, Lawrence, posterabstract, 15(1997)
52. 戸塚裕一, SiripomOkonogi, 米持悦生, 小口敏夫, 山本恵司:難溶性医薬品の溶出性改善を目的とした多孔性
結晶セルロースの利用。第41回日本薬学会関東支部大会講演要旨集 42(1997)
53. S.Limmatvapirat, 米持悦生, 小口敏夫, 山本恵司:デオキシコール酸との混合粉砕によるゲスト交換現象。
第14回製剤と粒子設計シンポジウム講演要旨集 172(1997)
54. T,Oguchi, A.Satoh, K.Fulita, E.Yonemochi and K.Yamamoto:Characterization of the Solid-State
Properties of Cromolyn Sodium, 12th Amual Meeting of American Association of Pharmaceutical
Scientists, Boston, Invited and Contributed Papers Abstracts, s-202(1997)
55. E.Yonemochi, G.Buckton, T.Oguchi and K.Yamamoto:Characterization of Ground and Quenched
Ursodeoxycholic Acid, 12t hAnnual Meeting of American Association of Pharmaceutical Scientists,
Boston, Invited and Contributed Papers Abstracts, s-229(1997)
56. 山本恵司:粉砕法,噴霧乾燥法による分子結晶の非晶質化。 第15回物性物理化学研究会講演要旨集 23(1997)
1998-1999
57. 小口敏夫:製剤設計・開発のための新しい物性測定法. 創剤フォーラム第4回若手研究会講演要旨集, 119(1998)
58. 内野智信, 小口敏夫, 山本恵司, 米持悦生:アミロースヘの薬品包接化挙動に及ぼす水分の影響。
第15回製剤と粒子設計シンポジウム講演要旨集, 87(1998)
59. E.Yonemochi, G.Buckton, J.Hammond and A.Moffat:Near-IR Detection of Change in the Form of Amorphous
and Crystalline Lactose, Proceedings of 2nd World Meeting on Pharmaceutics,
Biopharmaceutics and Pharmaceutical Technology, Paris, France, 13-14(1998).
60. K.Yamamoto, T.Oguchi, E.Yonemochi, S.Limmatvapirat and K.Terada:Complex Formation and
Guest Exchange Phenomena of Deoxycholic Acid-Guest Systems Induced by Mechanochemical Process,
Proceedings of 2nd World Meeting on Pharmaceutics,
Biopharmaceutics and Pharmaceutical Technology, Paris, France, 23-24(1998).
61. G.Buckton, E.Yonemochi, W.LYoon and A.Moffat:The Use of NIR Spectroscopy to Study the
Difference between Emcocel and Prosolv SMCC Before and After Wet Granulation.
Proceedings of the 17th Pharmaceutical Technology Conference and Exhibition, Dublin, Ireland, 3, 17-27(1998)
62. E.Yonemoch, G.Buckton and A.Moffat:Characterising Amorphous and Crystalline Trehalose and
Raffinose:Near IR Studies. American Association of Pharmaceutical Scientists Annual Meeting & Exposition,
San Francisco, CA, USA, Pharm.Sci. s-p 404(1998)
63. G.Buckton and E.Yonemochi:Near IR Spectroscopy of Microcrystalline Cellulose and Ccolloidal
Silica, as Physical Mixtures and Prosolv SMCC. American Association of Pharmaceutical Scientists Annual Meeting & Exposition,
San Francisco, CA, USA, Pharm.Sci. s-309(1998)
64. G.Buckton and E.Yonemochi, W.LYoon and A.Moffat:Characterisation of Microcrystalline Cellulose
and Silicified Microcrystalline. American Association of Pharmaceutical Scientists Annual Meeting & Exposition,
San Francisco, CA, USA, Pharm.Sci. s-309(1998)
65. 小口敏夫, 風間和夫, S.Chutimaworapan, 山本恵司, 米持悦生:ウルソデオキシコール酸と薬品の粉砕複合化におよぼす温度の影響.
日本薬学会第14年会講演要旨集, 171(1999)
66. 太田真人, 小口敏夫, 山本恵司:Cefditoren Pivoxil非晶質紛体の表面キャラクタリゼーション.
日本薬剤学会第14年会講演要旨集, 172(1999)
67. 戸塚裕一, 米持悦生, 小口敏夫, 山本恵司:蛍光測定法による多孔性紛体中での2-Naphthoic Acidの吸着状態に関する研究.
日本薬学会第119年会講演要旨集 4, 21(1999)
68. 内野智信, 小口敏夫, 山本恵司:アミロースとの密封過熱過程における2-ナフトールの包接化挙U−水分の影響−.
日本薬学会第119年会講演要旨集 4, 22(1999)
69. 米持悦生, 寺田勝英, G.Buckton, 小口敏夫, 山本恵司:非晶質Ursodeoxycholic acidの結晶化挙動と粉体物性との関係.
日本薬学会第119年会講演要旨集 4, 19(1999)
70. L.Zhou, J.Sirithunyalug, T.Oguchi and K.Yamamoto:Complex Formation Between Erythritol and 4-Hexylresorcinol.
Conference on Challenges for Drug Delivery and Pharmaceutical Tcchnology, Tokyo, Japan, Abstracts, 181(1998)
71. S.Piyarom, E.Yonemochi, T.Oguchi and K.Yamamoto:Effect of Grinding on Crystallinity and
Water Sorption Characteristics of DL-Valine.
Conference on Challenges for Drug Delivery and Pharmaceutical Tcchnology, Tokyo, Japan, Abstracts, 182(1998)
72. Y.Y.Ng, P.P.L.Liew, K.Yamamoto, E.Yonemochi, T.Oguchi and P.C.Ho:Solubilization of All-Trans
Retinoic Acid with Cyclodextrin Derivatives.
Conference on Challenges for Drug Delivery and Pharmaceutical Tcchnology, Tokyo, Japan, Abstracts, 185(1998)
73. 小口敏夫:ミクロな視点から見た製剤工学. 第43回日本薬学会関東支部大会講演要旨集, 10(1999)
74. S.Okonogi, 小口敏夫, 山本恵司, 米持悦生, S.Puttipipatkachon:細孔径の異なる多孔性ガラス粉体と
Ursodeoxycholic acid(UDCA)との相互作用. 第43回日本薬学会関東支部講演要旨集, 42(1999)
75. 内野智信, 戸塚裕一, 小口敏夫, 山本恵司:アミロース包接化合物形成に及ぼすゲスト分子の影響.
第43回日本薬学会関東支部大会講演要旨集, 42(1999)
76. 殖栗まどか, 戸塚裕一, 小口敏夫, 山本恵司:温度変調DSCを用いた多孔性ガラス粉体と医薬品との相互作用の
検討. 第43回日本薬学会関東支部大会講演要旨集, 43(1999)
77. 戸塚裕一, 田代恵美, 小口敏夫, 山本恵司:揮発性薬品の多孔性結晶セルロースヘの吸着メカニズム.
第16回製剤と粒子設計シンポジウム講演要旨集, 174(1999)
78. K.Yamamoto, M.Ohta, Y.Tozuka and T.Oguchi:Physicochemical Characterization of Amorphous Cefditoren Pivoxil,
136th British Pharmaceutical Conference Science Prodeedings, Cardiff, UK, s-280(1999)
79. Y.Tozuka, T.Oguchi and K.Yamamoto:Flurometric Study of Molecular States of Drugs on Porous Material.
American Association of Pharmaceutical Scientists Annual Meeting & Exposition,
New Orleans, LA, USA, Pharm.Sci. s-156(1999)
2000-2001
80. 田代恵美, 戸塚裕一, 小口敏夫, 山本恵司:多孔性添加剤へのナフタレンの吸着挙動.
日本薬学会第120年会要旨集 3, 123(2000)
81. 水谷真悠子, 戸塚裕一, 小口敏夫, 山本恵司:混合粉砕によるコール酸とイブプロフェンとの包接化合物形成について.
日本薬学会第120年会要旨集 3, 123(2000)
82. 内野智信, 戸塚裕一, 小口敏夫, 山本恵司:ゲスト化合物との密封加熱法によるアミロースヘリックスの構造変化.
日本薬学会第120年会要旨集 3, 123(2000)
83. 佐藤貴幸, 戸塚裕一, 小口敏夫, 山本恵司:UDCA−フェナントレンのメカノケミカル複合化における粉砕温度の影響.
日本薬学会第120年会要旨集 3, 124(2000)
84. T.Oguchi:Crystallization and Molecular Interaction of Drugs during Pharmaceutical Manufacturing Processes.
15th Annual Meeting of the Academy of Pharmaceutical Science and Technology, Japan, Jointed
by the Association de Pharmacie Galenique Industrielle, San Francisco, Califomia, USA, 15-17(2000)
85. K.Yamamoto:Crystalhne form Optimization for Formulation.
Millennial World Congress of Pharmaceutical Sciences, San Francisco, Califomia, USA, 14(2000)
86. M.Ohta, Y.Tozuka, T.Oguchi and K.Yamamoto:WaterVaporAdsorptionPropertiesofAmorphous
Cefditren Pivoxil Evaluated by Adsorption Isotherms and Microcalorimetry.
Millennial World Congress of Pharmaceutical Sciences, San Francisco, Califomia, USA, 103(2000)
87. T.Uchino, Y.Tozuka, T.Ogucki and K.Yamamoto:
Change of Amylose Helical Structure Induced by Sealed Heating with a GuestCompound.
Millennial World Congress of Pharmaceutical Sciences, San Francisco, Cahfomia, USA, 120(2000)
88. Y.Tozuka, E.Tashiro, T.Oguchi and K.Yamamoto:EffectofPhysico-chemical Properties of
Porous Materials on the Adsorption Profile of Medicinals.
Millennial World Congress of Pharmaceutical Sciences, San Francisco, Califomia, USA, 115(2000)
89. T.Oguchi, K.Kazama, Y.Tozuka, E.Yonemochi and K.Yamamoto:
Temperature Effecton Mechanochemical Complexation of Ursodeoxycholic Acid with a Guest Compound.
Millennial World Congressof PharmaceuticalSciences, SanFrancisco, Califomia, USA, 115(2000)
90. S.Puttipipatkhachon, J.Nunthanid and K.Yamamoto:
Molecular Interaction between Drug and Chitosan in Casted Film.
Millennial World Congress of Pharmaceutical Sciences, SanFrancisco, Cahfomia, USA, 115(2000)
91. A.Wongmekiat, 戸塚裕一, 小口敏夫, 山本恵司:混合粉砕によるプランルカスト微粒子の形成とその評価.
第17回製剤と粒子設計シンポジウム講演要旨集, 159(2000)
92. Y.Tozuka, T.Oguchi and K.Yamamoto:
Effect of Surface Properties of Porous Materials on Adsorption Profileof Naphthalene.
First Asian Particle Technologry Symposium, Bangkok, Thailand, 237(2000)
93. A.Ito, Y.Tozuka, H.Seki, T.Oguchi and K.Yamamoto:
Determination for Polymorphic Fractionof Clarithromycin using Solid-state NMR.
First Asian Particle Technology Symposium, Bangkok, Thailand, 235(2000)
94. H.Anzai, Y.Tozuka, T.Oguchi and K.Yamamoto:
Characterization of Sodium Deoxycholate(NaDC) Hydrates.
First Asia nParticle Technology Symposium, Bangkok, Thailand, 234, 2000
95. T.Sato, Y.Tozuka, T.Oguchi and K.Yamamoto:
Effect of Temperatureon Mechanochemical Complexation o fUrsodeoxycholic Acid with Phenanthrene.
First Asian Particle Technology Symposium, Bangkok, Thailand, 245(2000)
96. S.Okonogi, Y.Tozuka, S.Puttipipatkhachom, T.Oguchi and K.Yamamoto:
The Behavior of Ursodeoxycholic Acid in Porous Particles.
First Asian Particle Technology Symposium, Bangkok, Thailand, 236(2000)
97. B.Sethabouppha, S.Puttipipatkhachon, Y.Tozuka, T.Oguchi and K.Yamamoto:
Amorphization of Dihydroartemisinin by Co-grinding with Additives.
Firs tAsian Particle Technology Symposium, Bangkok, Thailand,244(2000)
98. W.S.Choi, H.Y.Chung, H.Y.Chung, K.Yamamoto, T.Oguchi, Y.Tozuka, E.Yonemochi and K.Terada:
Amorphous and Nano-particle Preparation for Improvement of Insoluble Drugs Bioavailability.
First Asian Particle Technology Symposium, Bangkok, Thailand, 25(2000)
99. 山本恵司:Thermal Analysis for Mechanochemical Changes in Pharmaceutical Process.
第36回熱測定討論会要旨集 MS1-1A(2000)
100. 山本恵司:医薬品の熱分析. 第46回熱測定講習会要旨集, 40-45(2000)
101. 戸塚裕一, 小口敏夫, 山本恵司:シリカ多孔体FSM-16存在下でのサリチルアミドの分子分散状態.
日本薬学会第121年会講演要旨集 3, 99(2001)
102. 小野誠, 戸塚裕一, 小口敏夫, 山本恵司:テオフィリン無水物の吸湿速度および溶解速度に及ぼす水和水の脱水温度の影響.
日本薬学会第121年会講演要旨集 4,106(2001)
103. 鈴木達也, 菊池寛, 米持悦生, 寺田勝英, 山本恵司:撹拝造粒穎粒における結晶セルロースとの相互作用.
日本薬学会第121年会講演要旨集 3, 101(2001)
104. 安西浩之, 戸塚裕一, 小口敏夫, 山本恵司:デオキシコール酸ナトリウム水和物のキャラクタリゼーション.
日本薬剤学会16年会講演要旨集, 178(2001)
105. 伊藤弘一, 松井伸一, 戸塚裕一, 小口敏夫, 山本恵司:難溶性薬物N-4472のマイクロエマルジョン製剤の設計.
日本薬剤学会第16年会講演要旨集, 185(2001)
106. 水谷真悠子, 戸塚裕一, 小口敏夫, 山本恵司:イブプロフェン光学異性体とコール酸との混合粉砕.
日本薬剤学会16年会講演要旨集, 124(2001)
107. 深水啓朗, 戸塚裕一, 小口敏夫, 山本恵司:混合粉砕によるコール酸類の複合体形成−熱量測定を用いたアプローチ−.
日本薬剤学会第16年会講演要旨集, 123(2001)
108. 伊藤敦俊, 戸塚裕一, 小口敏夫,山本恵司:固体NMRを用いたクラリスロマイシン多形の定量.
日本薬剤学会第16年会講演要旨集, 179(2001)
109. 内野智信:直鎖アミロースと薬品の相互作用. 薬剤学懇談会要旨集, 81(2001)
110. T.Oguchi, A.Wongmekiat, Y.Tozuka and K.Yamamoto:
Particle Formation of Pharmaceuticals by Cogrinding with Cyclodextrins.
Intemational Symposium on‘Nanoparticles:Aerosols and Materials’, Pusan, Korea, 105(2001)
111. 戸塚裕一:多孔性粉体中での薬物吸着挙動に関する研究. 第26回製剤セミナー要旨集, 19-20(2001)
112. N.Sasaki, Y.Tozuka, T.Oguchi and K.Yamamoto:
Thermal Behavior of Ground Chenodeoxycholic Acid.
61st International Congress of FIP, Singapore, s76(2001)
113. T.Fukami, T.Sato, Y.Tozuka, T.Oguchi and K.Yamamoto:
Complex Formation of Cholic Acids by Co-Grinding.
61st Intemational Congress of FIP, Singapore, s77(2001)
114. 戸塚裕一:多孔性粉体中での薬品分子状態の研究.
平成13年度第1回粉体操作に伴う諸現象に関する勉強会要旨集, 2(2001)
115. T.Uchino, Y.Tozuka, T.Oguchi and K.Yamamoto:
Inclusion Compound Formationof Amyloseby Sealed-heating with Salicylic Acid Analogues,
138th British Pharmaceutical Conference, Glasgow, UK, 265(2001)
116. T.Oguchi, A.Wongmekiat, K.Sakata, Y.Tozuka and K.Yamamoto:
Mechanochemistry of Water Insoluble Drugs and Nanoparticle Formation,
138th British Pharmaceutical Conference, Glasgow, UK, 264(2001)
117. M.Ono, Y.Tozuka, T.Oguchi and K.Yamamoto:
Effect of Dehydration on Moisture Absorption and Dissolution Behavior of Theophylline and Carbamazepine,
138th British Pharmaceutical Conference, Glasgow, UK, 150(2001)
118. 戸塚裕一, A.Wongmekiat, 小口敏夫, 山本恵司:シクロデキストリンとの混合粉砕による医薬品微粒子の調製.
第19回シクロデキストリンシンポジウム講演要旨集, 38(2001)
119. Y.Tozuka, S.Sasaoka, T.Oguchi and K.Yamamoto: Molecular State of Sahcylamide
on Mesoporous Silica FSM-16. American Association of Pharmaceutical Sciences
Annual Meeting & Exposition, Denver, Colora, USA, s2121(2001)
120. A.Wongmekiat, Y.Tozuka, T.Oguchi and K.Yamamoto: Formation of Drug
Fine Particle by Cogrinding with Cyclodextrins. American Association of
Pharmaceutical Sciences Annual Meeting & Exposition, Denver, Colorado,
USA, s2053(2001)
121. 内野智信, 戸塚裕一, 小口敏夫, 山本恵司:アミロース薬品包接化挙動に及ぼす加熱温度の影響.
第18回製剤と粒子設計シンポジウム要旨集, 229(2001)
122. 佐々岡沙羅, 戸塚裕一, 小口敏夫, 山本恵司:シリカ多孔体(FSM-16)中での安息香酸の分子状態の検討.
第18回製剤と粒子設計シンポジウム講演要旨集, 127(2001)
2002-2003
123.川田大, 戸塚裕一, 小口敏夫, 山本恵司:超臨界CO2中での非晶質デオキシコール酸の結晶化挙動.日本薬学会第122年会講演要旨集3, 8 (2002)
124.堤俊一郎, 戸塚裕一, 小口敏夫, 山本恵司:超臨界CO2を用いた医薬品粉体の調製.日本薬学会第122年会講演要旨集3, 9 (2002)
125.坂田圭子, 戸塚裕一, 小口敏夫, 山本恵司:難溶性薬物ONO-8713のナノサスペンションの形成.日本薬学会第122年会講演要旨集3, 18 (2002)
126.A. Pongpeerapat, 伊藤弘一, 戸塚裕一, 小口敏夫, 山本恵司:難溶性医薬品-PVP-SDS三成分系混合粉砕試料からのナノパーティクルの形成.日本薬学会第122年会講演要旨集3, 18 (2002)
127.佐々岡沙羅, 内野智信, 戸塚裕一, 小口敏夫, 山本恵司:シリカ多孔体(FSM-16)中での安息香酸の分子状態:固体NMRによる考察.日本薬学会第122年会講演要旨集3, 18 (2002)
128.伊藤弘一, 戸塚裕一, 小口敏夫, 山本恵司:難溶性薬物N-4472マイクロエマルジョン粒子のキャラクタリゼーション.日本薬剤学会第17年会講演要旨集, 200 (2002)
129.深水啓朗, 戸塚裕一, 小口敏夫, 山本恵司::混合粉砕によるコール酸類の複合体形成メカニズムの検討.日本薬剤学会第17年会講演要旨集, 161 (2002)
130.竹下綾, 内野智信, 戸塚裕一, 小口敏夫, 山本恵司:アミロースとの密封加熱包接化に及ぼすp-アミノ安息香酸エステルのアルキル鎖長の影響.日本薬剤学会第17年会講演要旨集, 280 (2002)
131.K. Papangkorn, A. Barry, K. Moribe, A.A. Baig, W.I. Higuchi: Effects of low solution fluoride levels on CAP solubility. 80 th International Association of Dental Research, San Diego, USA, 102 (2002)
132.K. Yamamoto: Improvement of dissolution characteristic of poorly soluble drugs ―recent drugs. The 1st Korea-Japan Joint Symposium on Drug Delivery and Therapy, Seoul, Korea, s27 (2002)
133.S. S. Kwak, H. Y. Chung, H. I. Kim, H. -Y. Chung, W. S. Choi, K. Yamamoto, T. Oguchi, Y. Tozuka, E. Yonemochi, K. Terada: Amorphous and nano-particle preparation for improvement of insoluble drugs bioavailability: grinding characteristics of fine grinding mills. The 1st Korea-Japan Joint Symposium on Drug Delivery and Therapy, Seoul, Korea, s91 (2002)
134.H. I. Kim, S. S. Kwak, H. Y. Chung, H. -Y. Chung, W. S. Choi, K. Yamamoto, T. Oguchi, Y. Tozuka, E. Yonemochi, K. Terada: Amorphous and nano-particle preparation for improvement of insoluble drugs bioavailability: grinding characteristics of phenytoin. The 1st Korea-Japan Joint Symposium on Drug Delivery and Therapy, Seoul, Korea, s92 (2002)
135.Y. Tozuka, S. Sasaoka, W.S. Choi, T. Oguchi, K. Yamamoto: Molecular state of benzoic acid onto porous silica FSM-16. The 1st Korea-Japan Joint Symposium on Drug Delivery and Therapy, Seoul, Korea, s166 (2002)
136.K. Terada, W. S. Choi, Y. Tozuka, T. Oguchi, K. Yamamoto, E. Yonemochi: Factors affecting the solubility of ursodeoxycholic acid caused by grinding. The 1st Korea-Japan Joint Symposium on Drug Delivery and Therapy, Seoul, Korea, s173 (2002)
137.S. Tsutsumi, Y. Tozuka, T. Oguchi, K. Yamamoto: Fine powder preparation of phenylbutazone via supercritical solution. The 1st Korea-Japan Joint Symposium on Drug Delivery and Therapy, Seoul, Korea, s262 (2002)
138.山本恵司:粉末X線回折および熱分析による結晶多形の同定. 第1回製剤機械技術研究会教育研修会, 1 (2002)
139.A. Pongpeerapat, K. Itoh, Y. Tozuka, T. Oguchi, K. Yamamoto: Fine particle formation from ternary ground mixture of poorly water-soluble drug/ PVP/ SDS. 医療薬学フォーラム2002, 要旨集174 (2002)
140.A. Wongmekiat: 戸塚裕一, 小口敏夫, 山本恵司:シクロデキストリン類との混合粉砕による医薬品微粒子生成:水分量の影響. 第20回シクロデキストリンシンポジウム講演要旨集, 2 (2002)
141.王 斉放, 戸塚裕一, 小口敏夫, 山本恵司:密封加熱による安息香酸とトリアセチル−β−シクロデキストリンの包接化合物形成. 第20回シクロデキストリンシンポジウム講演要旨集, 122 (2002)
142.堤俊一郎, 戸塚裕一, 小口敏夫, 山本恵司:超臨界溶液の急速膨張法による医薬品の微粒子化. 第19回製剤と粒子設計シンポジウム講演要旨集.1 (2002)
143.坂田圭子, 戸塚裕一, 小口敏夫, 山本恵司:混合粉砕法による難水溶性薬物ONO-8713のナノパーティクル形成. 第19回製剤と粒子設計シンポジウム講演要旨集. 148 (2002)
144.W. S. Choi, S. S. Kwak, H. I. Kim, H.-Y. Chung, H. Y. Chung, K. Yamamoto, T. Oguchi, Y. Tozuka, E. Yonemochi, K. Terada: Amorphous and nano-particle preparation for improvement of insoluble drugs bioavailability: grinding characteristics of fine grinding mills. 10th European Symposium on Comminution, Heidelberg, Germany, C1-2 (2002)
145.Y. Tozuka, D. Kawada, T. Oguchi, K. Yamamoto: Supercritical carbon
dioxide treatment as a new method for polymorph preparation of deoxycholic
acid. 2002 American Association of Pharmaceutical Sciences Annual Meeting
& Exposition, Tronto, Canada, W4345 (2002)
146.戸塚裕一:超臨界流体を利用した医薬の調製とその評価. 創剤フォーラム第8回若手研究会講演要旨集1 (2002)
147.K. Yamamoto: Sub-micron particle formation of the insoluble drugs, pranlukast, cogrinding with cyclodextrins. Thirty-Sixth Annual Higuchi Research Seminar(2003)
148.王斉放, 戸塚裕一, 森部久仁一, 小口敏夫, 山本恵司:超臨界二酸化炭素を用いた医薬微粒子の調製. 日本薬学会第123年会講演要旨28[P1]I-212 (2003)
149.森部久仁一, 百武有紀, 戸塚裕一, 小口敏夫, 山本恵司:カフェインおよびアンピシリンの物理化学的性質に及ぼす脱水温度の影響. 日本薬学会第123年会講演要旨28[P1]I-217 (2003)
150.戸塚裕一, 堤俊一郎, 森部久仁一, 小口敏夫, 山本恵司:超臨界二酸化炭素を用いた医薬微粒子の調製. 日本薬学会第123年会講演要旨28[P1]I-218 (2003)
151.矢田修一, 大矢昌沖, 大内裕子, 濱浦健司, 脇山尚樹, 碓井富佐雄, 草井章, 山本恵司:CS-891 の結晶多形と粉砕による非晶質化に関する研究. 日本薬学会第123年会講演要旨28[P2]I-528 (2003)
152.土屋雅海, 戸塚裕一, 森部久仁一, 小口敏夫, 山本恵司:混合粉砕によるチオ尿素-エテンザミド複合体形成.日本薬剤学会第18年会講演要旨集138 (2003)
153.A. Pongpeerapat, 伊藤弘一, 戸塚裕一, 森部久仁一, 小口敏夫、山本恵司:難溶性医薬品/PVP/SDS三成分系混合粉砕試料からのナノパーティクル形成: PVP分子量の影響.日本薬剤学会第18年会講演要旨集144 (2003)
154.戸塚裕一, 坂田圭子, 森部久仁一, 小口敏夫, 山本恵司:難溶性薬物ONO-8713の微粒子化に及ぼす種々の要因. 日本薬剤学会第18年会講演要旨集189 (2003)
155.森部久仁一, 竹下 綾, 戸塚裕一, 小口敏夫, 山本恵司:密封加熱によるp-アミノ安息香酸のアミロースとの包接化に関する研究.日本薬剤学会第18年会講演要旨集216 (2003)
156.山本恵司, 坂田圭子, 戸塚裕一, 森部久仁一, 小口敏夫:混合粉砕法による難水溶性薬物の微粒子生成:シクロデキストリンの果たす役割. 第21回シクロデキストリンシンポジウム講演要旨集 123 (2003)
157.永江綾子, 戸塚裕一, 森部久仁一, 関 宏子, 小口敏夫, 山本恵司:固体 NMR 測定による医薬品-アミロース包接化合物の分子状態の検討. 日本分析化学会第52年会講演要旨集387 (2003)
158.K. Yamamoto: Preparation and characterization of amorphous pharmaceutical solid. XVth International Symposium on the Reactivity of Solids (2003)
159.正木美雪, 戸塚裕一, 森部久仁一, 小口敏夫, 山本恵司:混合粉砕によるコール酸−パラベン類複合体形成:ゲストサイズの影響. 第47回日本薬学会関東支部大会講演要旨集48 (2003)
160.土屋雅海, 戸塚裕一, 森部久仁一, 小口敏夫, 山本恵司:粉砕によるチオ尿素−エテンザミド複合体形成メカニズムの検討. 第47回日本薬学会関東支部大会講演要旨集 48 (2003)
161.山本恵司:日本薬局方に収載されている医薬品の物性評価法 熱分析の基礎. 第2回製剤機械技術研究会教育研修会, 1 (2002)
162.Y. Tozuka, K. Sakata, K. Moribe, T. Oguchi, K. Yamamoto: Fine particle
formation of poorly water-soluble drug by co-grinding with cyclodextrins.
2003 American Association of Pharmaceutical Sciences Annual Meeting &
Exposition, Salt Lake City, Utah, USA, W4328 (2003)
163.K. Moribe, M. Tsuchiya, Y. Tozuka, K. Yamaguchi, T. Oguchi, K. Yamamoto:
Thiourea- ethenzamide complex formation induced by grinding:A novel equimolar
structure and factors affecting the complex formation. 2003 American Association
of Pharmaceutical Sciences Annual Meeting & Exposition, Salt Lake City,
Utah, USA, W4293 (2003)
164.木村恭子, 戸塚裕一, 森部久仁一, 山村重雄, 小口敏夫, 山本恵司:シリカ多孔体(FSM-16)とFlurbiprofenとの相互作用; 小角X線散乱とN2ガス吸着による考察. 第20回製剤と粒子設計シンポジウム講演要旨集 185 (2003)
165.A. Wongmekiat: 戸塚裕一, 森部久仁一, 山村重雄, 小口敏夫, 山本恵司:シクロデキストリンとの混合粉砕による難溶性医薬品微粒子生成メカニズムの検討. 第20回製剤と粒子設計シンポジウム講演要旨集 198 (2003)
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6. 山本恵司:粉体の比表面積測定法に関する検討.公定書協会「日本薬局方の試験法に関する研究」研究報告(2001)
7. 山本恵司:医薬品製造工程等の変更が品質に与える影響および品質確保のあり方に関する研究
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8. 山本恵司(分担):医薬品の品質に及ぼす添加剤の物理化学的性質の影響.:粉砕時に添加剤の水分含量が医薬品粒子径に与える効果.厚生科学研究費補助金(医薬安全総合研究事業)分担研究報告書(2003)
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